Primary HIV infection during chronic treatment with imatinib: impact on infection dynamics

Western blot analysis revealed that imatinib at 5 μM induced a 5.8-fold reduction in phosphorylated SAMHD1, indicating potential interference with CD4 + permissivity to HIV reverse transcription, whereas imatinib at 1.25 μM induced only a partial reduction that did not reach statistical significance (Fig. 1 b).

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