Chronic activation of a negative engram induces behavioral and cellular abnormalities.

However, we observed a strong trend showing an increase in freezing in the 6-month-old hM3Dq mice that was like remote recall (two-way ANOVA; interaction: F(1,41) = 2.618, p=0.1133; age: F(1,41) = 2.335, p=0.1342; group: F(1,41) = 5.763, p=0.0210; Tukey’s [group]: 6MO mCherry vs. hM3Dq, p=0.0590; 14MO mCherry vs. hM3Dq, p=0.9269) ( Figure 4di–ii ).

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