Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD mice.

Western blotting indicated that BACE1 protein levels were significantly decreased in male 5xFAD mice overexpressing DUSP6, while female 5xFAD mice overexpressing DUSP6 showed a trend of reduction in BACE1 protein levels ( Figure 3E ).

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