Furthermore, the expression of inflammatory cytokines and chemokines and ISGs was strongly suppressed in the skin of ZBP1ca E-het Mlkl AA/AA compared to ZBP1ca E-het mice, however, ZBP1ca E-het Mlkl AA/AA animals showed a trend toward higher expression of Oasl1 , Cxcl9 , Tnf and Il-6 compared to K14-Cre negative control mice (Fig. 6G ).
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ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis.
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