The Significant Associations between Epigenetic Clocks and Bladder Cancer Risks.

These two highly significant SNPs were rs1005277 near the ZNF25 gene (OR = 1.45, 95% CI, 1.29–1.62, p = 3.68 × 10 −10 ) and rs12417758 in a long non-coding RNA (lncRNA) gene, RP11-867G23.13 (OR = 1.22, 95% CI, 1.11–1.34, p = 3.66 × 10 −5 ).

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Modestly increased bladder cancer risks were observed for individuals with high GRS for HorvathAge compared to those with low GRS in the dichotomized and quartile analyses, but these analyses did not reach statistical significance ( Table 4 ). 3.4.

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