Genetic Testing of Breast Cancer Patients with Very Early-Onset Breast Cancer (≤30 Years) Yields a High Rate of Germline Pathogenic Variants, Mainly in the BRCA1, TP53, and BRCA2 Genes.

Although this analysis did not reach statistical significance, TP53 carriers had the worst EFS (survival frequency: 0.364; 95% CI, 0.132–1; p = 0.38), compared to carriers in other cancer-predisposing genes (survival frequency: 0.667; 95% CI, 0.402–1, p = 0.38) ( Supplementary Figure S1 ).

also in 111,027 other papers