INT-1B3, an LNP formulated miR-193a-3p mimic, promotes anti-tumor immunity by enhancing T cell mediated immune responses via modulation of the tumor microenvironment and induction of immunogenic cell death.

In addition, INT-1B3-treated tumors revealed a strong trend towards increased expression of Cxcl5 , Cxlc9 and Cxcl10 (Supplementary Figure 5B), T cell recruiting chemokines, which is consistent with increased levels of CD8+ T cells.

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