Induction of apoptosis by double-stranded RNA was present in the last common ancestor of cnidarian and bilaterian animals.

The increase in Caspase-3 activity relative to 6 hours was most noticeable at 24 hours (p = 0.145, n = 3, one way ANOVA test) after injection and decreased in magnitude at 48 hpi (p = 0.469, n = 3, one way ANOVA test), however, these differences did not reach statistical significance ( Fig 4D ).

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