Other SLE-associated SNPs such as those located in STAT1 or the intergenic region at chromosome 5 nearby microRNA mir-146 also showed a significant indirect effect of SNP on SLE suggesting a mediation role of DNAm, but the proportion mediated did not reach statistical significance ( P > 0.05), probably due to the low sample size.
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Molecular subtypes explain lupus epigenomic heterogeneity unveiling new regulatory genetic risk variants.
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