Electrical stimulation of the vagus nerve ameliorates inflammation and disease activity in a rat EAE model of multiple sclerosis.

While these area reductions assessed at a single timepoint (3 to 4 DPSO) and with relatively small sample size did not reach statistical significance, evaluation of clinical symptoms across the entire observation period revealed that VNS treatment significantly attenuated both severity and duration of EAE, which is also reflected by a corresponding significant attenuated loss of body weight.

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