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Rational design of structure-based vaccines targeting misfolded alpha-synuclein conformers of Parkinson's disease and related disorders.

Bioeng Transl Med · 2024 · PMC11256163 · PMID 39036077

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α‐SC8 antisera could significantly differentiate [p <0.0001] pathological fibrils derived from brains of patients with DLB, but its reactivity for MSA and PD samples did not reach statistical significance in comparison to the non‐neurological controls (Figure 6c ).

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