In addition, we detected a nominally significant positive correlation between cg05649751 methylation and the expression of one of its cis -genes, SH2B3 , which encodes a critical negative regulatory protein in cytokine signaling and was reported to be associated with the risk of lung, colorectal, and breast cancer 32 .
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Integrating muti-omics data to identify tissue-specific DNA methylation biomarkers for cancer risk.
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