Key factor screening in mouse NASH model using single-cell sequencing combined with machine learning.

The above results indicated a highly significant correlation between core genes and immune cells in NASH. 3.6 Deep learning validation of immune correlations We further employed a convolutional neural network (CNN) to analyze gene expression data related to NASH.

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We discovered key features in the NASH liver, including a dramatically reduced proportion of liver sinusoidal endothelial cells and a significant trend where monocytes developed into Kupffer cells, underscoring the critical role of macrophages in NASH progression.

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