13 In that same analysis, we observed an encouraging trend towards better survival outcomes associated with such a molecular downstaging. 13 In a small study from Hilal et al., 28 NET induced a reduction in ER and PgR, consistent with our findings, though a slight increase in molecular risk of relapse, as detected with the 21-gene Oncotype DX® assay, was observed.
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Unraveling the clinicopathological and molecular changes induced by neoadjuvant chemotherapy and endocrine therapy in hormone receptor-positive/HER2-low and HER2-0 breast cancer.
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9 , 26 In our study, patients with HR+/HER2-low and HR+/HER2-0 disease seemed to experience comparable long-term outcomes, with marginal differences that did not reach statistical significance.