Stem cell-derived cardiomyocytes expressing a dominant negative pacemaker HCN4 channel do not reduce the risk of graft-related arrhythmias.

7.5% ± 1.9 of infarct area, respectively), but this difference did not reach statistical significance and was largely due to a single WT recipient that showed an unusually large graft at 30 days post-transplantation. dnHCN4 mutation had no obvious effect on graft-related arrhythmias The primary endpoint in this study was the incidence and severity of graft-related arrhythmias by telemetric ECG, and both WT and dnHCN4 hPSC-CM recipients showed abundant and frequently lethal VT with morphology and time-course similar to that described in previous hPSC-CM transplantation studies ( 8 – 10 , 12 ).

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