nearly significantp = 0.052
In the United Kingdom Prospective Diabetes Study (UKPDS) conducted in newly diagnosed patients with T2D, intensive treatment (insulin and SU-based therapies) was associated with significant reduction in microvascular complications by 25% ( p = 0.0099) and a nearly significant decrease in macrovascular complications by 16% ( p = 0.052) compared with conventional treatment at 1 year [ 27 ].