The effect of human recombinant epidermal growth factor on neovascularization and pedicle division time in a rat interpolation flap model.

However, when the same comparison was made in the study group, although there was a decrease in the total necrosis area, it did not reach statistical significance (p = 0.115).When comparing the areas of flap necrosis between the study and control subgroups, in which pedicle division was performed on the same days, significant results were obtained on day 11 (p = 0.015), while the results obtained on days 8 and 14 were not statistically significant (p = 0.699, p = 0.589).Histopathologic data were compared between the study and control subgroups in which pedicle division was performed on the same day.

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