Extracellular vesicles released by LPS-stimulated spinal organotypic slices spread neuroinflammation into naïve slices through connexin43 hemichannel opening and astrocyte aberrant calcium dynamics.

Although this increase did not reach statistical significance in all the considered cases, we detected an explicit positive trend when LPS and sEV LPS were compared with controls, becoming statistically significant for TNF-α and CXCL10, while a statistically significant difference was observed when sEV LPS was compared with control in the cases of CXCL2 and CCL3.

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