The effects of ghrelin and LEAP-2 in energy homeostasis are modulated by thermoneutrality, high-fat diet and aging.

J Endocrinol Invest · 2024 · PMC11266414 · PMID 38337094

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Protein levels of other thermogenic proteins, including PRDM16, PPARα, and FGF21 were elevated, with a clear trend for UCP1 (Fig. 5 i), suggesting partial activation of the thermogenic program in LEAP-2-treated mice.

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