In the LEARN cohort, baseline PACC performance and age explained the most variance in decline, with much less, but nominally significant, variance explained by baseline amyloid PET and P-tau217, even in this Aβ- group.
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Amyloid and Tau Prediction of Cognitive and Functional Decline in Unimpaired Older Individuals: Longitudinal Data from the A4 and LEARN Studies.
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