Neuroinflammation in the medullary visceral zone exert a powerful impaction on the systemic inflammation in sepsis through cholinergic anti-inflammatory pathway.

Central anti-inflammation by minocycline not only significantly reduced MSS of both model rats, but also significantly improved the survival rate in the neuroinflammation model rats, and showed a trend of improving the survival rate in the sepsis model rats.

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However, right vagotomy abolished the reduction of MSS caused by central anti-inflammation, it also significantly reduced the survival rate in Central Anti-inflammatory Group of the neuroinflammation experimental group, and the increasing survival rate by central anti-inflammatory in the sepsis experimental group also showed a decreasing trend in the Vagus Transection Group, see Fig. 3 .

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