¹H-NMR-based metabolomics reveals metabolic alterations in early development of a mouse model of Angelman syndrome.

A tendency towards higher creatine levels in the AS was observed, although this did not reach statistical significance ( p = 0.052).

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Noteworthy, ‘glycolysis’ and ‘pyruvate metabolism’ were highly significant following FDR correction for multiple comparisons (FDR < 0.01 with mus musculus and FDR < 0.01 with human metabolic database), whereas ‘TCA cycle’ was nearing significance following FDR correction for multiple comparisons (FDR = 0.0577 for both databases) (Tables 2 and 3 ).

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Noteworthy, ‘glycolysis’ and ‘pyruvate metabolism’ were highly significant following FDR correction for multiple comparisons (FDR < 0.01 with mus musculus and FDR < 0.01 with human metabolic database), whereas ‘TCA cycle’ was nearing significance following FDR correction for multiple comparisons (FDR = 0.0577 for both databases) (Tables 2 and 3 ).

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