In the CF colon, apical DIDS showed a trend towards reducing baseline mucus growth, while SLC26A3-IN-2 reduced baseline mucus growth by 80% (Fig. 1 A).
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The anion exchanger slc26a3 regulates colonic mucus expansion during steady state and in response to prostaglandin E<sub>2</sub>, while Cftr regulates de novo mucus release in response to carbamylcholine.
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