Pan-serotype dengue virus inhibitor JNJ-A07 targets NS4A-2K-NS4B interaction with NS2B/NS3 and blocks replication organelle formation.

Nat Commun · 2024 · PMC11271582 · PMID 39030239

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did not reach statistical significanceno p-value reported

Whether Compound A has a higher affinity to mature NS4B or NS4A-2K-NS4B is unclear, because these comparisons did not reach statistical significance.

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