An updated immunosenescence exploration in healthy Chinese donors: circular elevated PD-1 on T cell and increased Ki67 on CD8+ T cell towards aging.

Consistent with previous studies [ 4 , 9 , 15 ], our data also confirm a clear trend of reversal of age-related naïve T cells and memory cells, especially in the CD8 population, which is attributed to long-term repeated exposure to antigens and decreased thymic function [ 1 , 8 , 27 ].

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Similarly, the percentage of CD8+ki-67+ also showed an increasing trend, with significant differences between the young group and other elderly groups in males.

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