Rational Design of Far-Red Archaerhodopsin-3-Based Fluorescent Genetically Encoded Voltage Indicators: from Elucidation of the Fluorescence Mechanism in Archers to Novel Red-Shifted Variants.

We chose to optimize red-shifting of λ max not only due to practical importance of red-shifted variants for biomedical applications but also because a clear trend between λ abs and fluorescence quantum yield was observed for microbial and animal rhodopsins (see, e.g., a review 48 ).

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