As hypoxia is a potent inducer of angiogenesis in the EB model, the effect of the Bhlhe40 knockout further increasing the vascularization of the EBs is more challenging to observe, and it did not reach statistical significance in the AngioTool parameters ( Figure 7 C,D).
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Bhlhe40 Regulates Proliferation and Angiogenesis in Mouse Embryoid Bodies under Hypoxia.
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