Consistent with this idea, even with the short duration of this treatment, we also found a nearly significant trend for reduced expression of Cluster of Differentiation 68 (CD68), a marker of pro-inflammatory microglia in Nanoligomer-treated old mice (Fig. 1 E).
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Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function with aging and tauopathy.
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