Dynamic dysregulation of transcriptomic networks in brainstem autonomic nuclei during hypertension development in the female spontaneously hypertensive rat.

Hypocretin ( Hcrt ), also known as orexin, which was detectable only in the NTS in the present data set, was downregulated in SHR versus WKY rats at the hypertension onset and showed a trend toward normalization by 24 wk ( Fig. 6 F ).

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