Renal Response Criteria for Clinical Trials in Amyloid Light Chain Amyloidosis.

Patients who had a 50% increase in proteinuria were more likely to have decline in renal function; however, this finding did not reach statistical significance. 37 Patients who met progression criteria per Kastritis were found to have an increased risk of progression to ESRD regardless of the criteria. 50 The relative risk of progression to ESRD was 4.233 ( P = 0.003) using the Kastritis model.

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