Evidence for prodromal changes in neuronal excitability and neuroinflammation in the hippocampus in young alpha-synuclein (A30P) transgenic mice.

In the very young juvenile animals aged just 1 month, however, the increase in the % area of GFAP did not quite reach statistical significance.

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For female mice there was a slight increase in Iba-1 count but this did not reach statistical significance ( Figure 6C ).

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We also found a highly significant increase in the number of Iba-1+ cells that co-labeled with iNOS ( Figure 5F ) in the 2–4 months male A30P mice (WT median count 11 per mm 2 , IQR 9.3–20.45, n / N = 12 sections/six mice, vs.

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