GLUT1 overexpression enhances CAR T cell metabolic fitness and anti-tumor efficacy.

Given the observed improvements in metabolic fitness and Tscm formation, we rechallenged treated mice with NALM6, and found that GLUT1-treated mice tended to have a lower tumor burden and higher numbers of CAR-T cells in bone marrow and spleen, but the differences did not reach statistical significance ( Figure S5 E).

also in 111,027 other papers