Targeting vascular disrupting agent-treated tumor microenvironment with tissue-penetrating nanotherapy.

Although the survival differences among mice treated with these combination therapies did not reach statistical significance, analysis of the tumor burden revealed that the CA4P + iRGD + UTO-PS combination treatment significantly decreased the overall tumor weight (Fig. 4 h), and this was the only treatment that resulted in a reduction in the number of tumor nodules (Fig. 4 i).

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