Genome-wide discovery for biomarkers using quantile regression at biobank scale.

In terms of p-value, 25 out of 58 tests are nominally significant ( p < 2.2 e − 308), with 6 out of 58 being significant after adjusting for 58 tests, including variants in TCF7L2 and age for Glycated hemoglobin (HbA1c), variants in SMOX and sex for High light scatter reticulocyte count, Reticulocyte percentage, and Immature reticulocyte fraction, variants in CSP1 and sex for Mean platelet (thrombocyte) volume.

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As mentioned above, one highly significant interaction was detected with rs1354034, a SNP with heterogeneous quantile effects that was completely missed by LR (Fig. 6 ).

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