Immune-Mediated and Psychiatric Comorbidities Among Patients Newly Diagnosed With Alopecia Areata.

15 Although the association between the severity of AA and the severity of depression and anxiety did not reach statistical significance (likely due to small sample size), the findings highlight the potential synergistic nature of AA and depression. 15 Therefore, it is perhaps unsurprising that AA has been consistently linked to high prevalences of psychiatric and autoimmune disorders and worse scores in health-related quality-of-life measures. 8 , 12 , 13 , 15 , 21 , 27 , 28 Moreover, the high prevalence of comorbidities is also associated with a high economic burden.

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