Spironolactone Reduces the Risk of Death in Veterans With Heart Failure With Preserved Ejection Fraction.

Conclusions In a real‐world national cohort of patients with HFpEF, spironolactone use reduced all‐cause death and demonstrated a favorable trend in reducing the burden of hospitalizations. heart failure with preserved ejection fraction mineralocorticoid antagonism outcomes real‐world studies spironolactone Subject Categories Heart Failure HFpEF patients in our cohort were 96% men, 85% White, and an average age of 74±11 years old at the beginning of follow‐up.

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However, we observed a reduction in days hospitalized for all‐cause (12%) and HF (26%) that did not reach statistical significance.

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