Exploring the causal effect between lipid-modifying drugs and idiopathic pulmonary fibrosis: a drug-target Mendelian randomization study.

SMR analysis also found that there was a tendency towards significance in the connection between high expression of the NPC1L1 gene in adipose subcutaneous and lower IPF risk (OR = 0.85, 95% CI: 0.73 – 1.00, P = 0.051) (Table S20).

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Although the original P -value may suggest an association between NPC1L1 and PCSK9 with IPF, the adjusted P -value indicates that this association may not be significant enough to rule out chance.

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