Intergenic risk variant rs56258221 skews the fate of naive CD4⁺ T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis.

Similar to CD4 + , CD8 + T cells showed a trend toward increased T N ( Figure 1 I, p = 0.064) but not for terminally differentiated T cells re-expressing CD45RA (T EMRA ) ( Figure 1 J, p = 0.325), which had previously been associated with changes in BACH2 levels in CD8 + T cells. 21 , 24 However, we observed an increased frequency of CD39-expressing CD8 + T cells, which points toward activated cells 28 in SNP carriers compared to non-carriers ( Figure 1 K, p = 0.003).

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