Accurate estimation of pathway activity in single cells for clustering and differential analysis.

However, SiPSiC was the only method to detect upregulation of both MYC target pathways in the active infection group, whereas AUCell missed the MYC target V2 pathway, producing a median score of zero for all T cell groups, and the two other methods failed to reach statistical significance for the MYC target V1 pathway ( Supplemental Fig.

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