Evolutionary and biomedical implications of sex differences in the primate brain transcriptome.

Although enrichments for sex hormone binding sites only approached significance in the uncorrected analyses (ER⍺: OR = 1.192, p = 0.069; Figure 4 D), the most highly enriched motifs in both analyses were for transcription factors (TFs) that interact with estrogens (e.g., SP1, which binds to estrogen receptor) 58 ( Table S14 ).

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