Multiple vaccine comparison in the same adults reveals vaccine-specific and age-related humoral response patterns: an open phase IV trial.

At 28 days post 2nd mRNA-1273 vaccination, a strong trend to a lower Spike S1-specific IgG concentration was observed in older adults compared to young adults (p = 0.065) (geometric mean IgG concentration in BAU/mL (95% CI): YA = 2587.8 (2203.9–3038.5), MA = 2217.9 (1874.5–2623.3), and OA = 1832.3 (1513.5–2218.3)) (Fig. 4A ).

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