Progress and recognition of idiopathic intracranial hypertension: A narrative review.

revealed that AG counts were higher in IIH patients than in healthy individuals; however, this difference did not reach statistical significance (2.41 ± 1.12 vs. 1.50 ± 0.54, p = 0.096). 81 Recent studies have suggested that AGs may not be as efficient as mature structures, which may represent fibrotic degeneration of the arachnoid villi. 84 Furthermore, many individuals with normal CSF systems lack AGs, suggesting that their actual

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103 , 104 Additionally, a highly significant positive correlation was found between the degree of blood–brain barrier leakage and astrocyte proliferation in IIH. 105 Despite the discovery of a link between the function of the glymphatic system and various central nervous system disorders, particularly degenerative conditions such as Alzheimer's disease and idiopathic normal‐pressure hydrocephalus, few studies have explored the impact of the glymphatic system on CSF circulation and ICP regulation.

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1 Recent studies have indicated an increasing trend in the sex‐adjusted and age‐adjusted annual incidence of IIH, currently estimated at 2.4 per 100,000.

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