Metagenomic analysis demonstrates distinct changes in the gut microbiome of Kawasaki diseases children.

The results of time series analysis for all differential pathways showed four main trends, and 22 differential pathways were included in cluster 1, which showed a trend of decrease first and then increase from control to Bef-IVIG to Aft-IVIG, such as acetyl-CoA fermentation to butanoate II, superpathway of Clostridium acetobutylicum acidogenic fermentation, folate transformations III (E. coli), and biotin biosynthesis II ( Figure 2A ).

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