Temporal trends in clinical features of patients with primary aldosteronism over 20 years.

However, in contrast to our findings regarding the decreasing trend of the clinical severity, including the prevalence of hypokalemia in both UHA and BHA subtypes, a Japanese study showed a trend toward milder severity associated with the duration of HTN and prevalence of hypokalemia in the BAH subtype but not in the APA subtype [ 19 ].

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The rate of AVS implementation showed an increasing trend from 70.0% in time period 1 to over 90% in time periods 2 and 3.

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