Clonal hematopoiesis of indeterminate potential as a prognostic factor: a systematic review and meta-analysis.

In a meta-analysis of 6 cohorts, CHIP was associated with an increased risk of myeloid malignancy (OR/HR, 4.34; 95% CI, 2.66-7.09) ( Figure 4 A), and in subgroup analyses, the risk was higher for TET2 (HR, 5.45; 95% CI, 2.22-13.38) and ASXL1 (HR, 6.16; 95% CI, 4.53-8.38) mutations compared with DNMT3A, in which the results failed to reach statistical significance (HR, 1.93; 95% CI, 0.78-4.77) ( Figure 4 B; supplemental Figure 11 ).

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