Barely Significant
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Physicochemical properties, biological chemistry and mechanisms of action of caries-arresting diammine-silver(I) fluoride and silver(I)-fluoride solutions for clinical use: a critical review.

Front Oral Health · 2024 · PMC11300431 · PMID 39108636

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quite significantno p-value reported
However, the solubility of CaF 2 is reported to be 1.6 mg/L at 20°C, equivalent to 20.5 μmol./L, which may be considered to be quite significant in at least some physiological contexts.

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