Insights into gemcitabine resistance in pancreatic cancer: association with metabolic reprogramming and TP53 pathogenicity in patient derived xenografts.

In the present study, the enrichment of OXPHOS and glycolysis at baseline and in drug-induced changes in resistant PDAC models was highly significant ( p < 0.001), however these pathways were not identified in the original transcriptional analysis of the Yang dataset [ 21 ].

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5 a), there was a lower prevalence of pathogenic TP53 variants in complete responders (2 out of 4, or 50%) compared to patients with progressive disease (6 out of 8, or 75%), but the association did not reach statistical significance ( p = 0.55).

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