Aldosterone Antagonist Dosing and the Risk of Hyponatremia in Patients With Cirrhosis and Ascites.

Gastro Hep Adv · 2023 · PMC11307619 · PMID 39130144

Europe PMC DOI

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The high-dose spironolactone cohort also showed a strong trend toward moderate hyponatremia by inverse probability of treatment-weighted Cox regression with propensity score adjustment on ITT (HR, 3.1; 95% CI, 0.9–10.9; P = .08) and CDC (HR, 2.1; 95% CI, 0.9–4.5; P = .07) analysis and exhibited a significantly shorter time to hyponatremia ( Figure A1 ).

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