Heterologous Prime-Boost with Immunologically Orthogonal Protein Nanoparticles for Peptide Immunofocusing.

We observed a higher frequency of K417N-peptide reactive FAS/CD95+ GC-derived and (to a lesser extent) CD19+ total B cells after heterologous immunization with PP7 and HEnc-PP7 (approach “2”) compared to PP7 homologous immunization in both lymph node and spleen, although the trends did not reach statistical significance due to the small number of animals used in this preliminary assessment ( Figures S22E,F and S23A,B ).

also in 111,027 other papers