Metabolic characteristics of transmembrane prolyl 4-hydroxylase (P4H-TM) deficient mice.

Although the HOMA-IR scores increased by aging in both genotypes, they were ~ 50% lower in the P4h-tm −/− mice at both 6 ( P = 0.086) and 12 months ( P = 0.06) in comparison to WT, yet this did not reach statistical significance (Fig. 3 c).

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